D-42 | Impact of Body Mass Index on Long-Term Mortality in Patients Undergoing Transcatheter Mitral Valve Replacement: A Systematic Review and Meta-Analysis

Obesity paradox has been linked to transcatheter mitral valve replacement (TMVR) patients in previous studies. Therefore, we set out compare long-term all-cause mortality among various body mass index (BMI) categories undergoing TMVR. Until January 2023, PubMed/Medline, Embase, Scopus, and Google Scholar were searched for studies on cardiovascular outcomes TMVR BMI/Obesity scales (Class 1: 30-34.9 kg/m2, Class 2: 35-39.9 3: ≥40 kg/m2). Random effect models used report pooled 1-year rates. A total of 5 (3 retrospective 2 prospective) including 31,142 (Mean age: 72.2 years, Males: 60%) included the analysis. Obese had higher prevalence hypertension, diabetes, coronary artery disease compared with normal BMI. In 3 meta-analysis, 1 or obesity did not show risk or, (HR: 0.87; 95% CI: 0.22-3.49) following Even, 0.77; 0.15-3.99) when only followed up year. However, was significantly 1.36; 1.08-1.71) long term follow-up [Fig. 1]. Severity years are more important predictors 1-year/long-term predicted nearly 35% HRs considered analysis accounting confounders.